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PGPeptide G™Science-forward skincare peptide
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Mechanism

Mechanism: melanocortins, MC1R, and adaptive pigmentation

A science-forward explanation of melanocortins, receptor biology, and the documentation-led positioning of Peptide G.

Melanocortins in the body

Melanocortins are small protein hormones derived from POMC that bind to melanocortin receptors (MC1R–MC5R). In skin, melanocortin signaling is closely tied to pigmentation and inflammatory modulation.

Alpha-MSH and the skin's protective response

Alpha-MSH is produced in response to UV exposure and binds to MC1R on melanocytes to stimulate eumelanin production. Eumelanin is transported to keratinocytes where it forms a protective barrier around nuclei.

Where Peptide G™ is positioned

Peptide G™ is positioned as a gamma-MSH class peptide approach that impacts the melanocortin system. Documentation describes tone modulation (darken or lighten), photoprotection pathway support, and additional skin benefits such as anti-inflammatory and anti-microbial action.